Heart Healthy Panko-Crusted Tilapia

(5.0)
By Judy Capodanno
Updated 10/21/2025
Dietitian Reviewed: Jane Schwartz, RDN, CLT
Approved for These Diets:
Heart Healthy | Diabetic
Heart Healthy Panko-Crusted Tilapia
Photo Credit: Baldwin Publishing Staff Photographer

Crunchy panko breadcrumbs create the flavorful crust of this healthy tilapia recipe. Fresh parsley, basil and black pepper give this bright seafood dish a well-balanced, savory edge that makes every bite sing. It's a perfect choice for a quick and healthy weeknight meal.

Total Time
35 minutes
Servings
4
Calories
181

What Makes This Panko-Crusted Tilapia Healthy

This recipe is designed to be heart-healthy by prioritizing smart cooking techniques and ingredients. Here’s a quick overview:

  • Baked, Not Fried: Baking the tilapia provides a crispy texture without the added saturated fats and calories that come from deep-frying.
  • Lean Protein: Tilapia is an excellent source of lean protein, which is essential for muscle maintenance and helps you feel full longer.
  • Flavor from Herbs: By using fresh herbs like parsley and basil, the recipe builds savory flavor without relying on excess sodium.

Key Health Highlights

  • Low in Fat: Each serving contains only 3 grams of total fat and 1 gram of saturated fat.
  • High in Protein: Delivers a substantial 30 grams of protein per serving to support your daily nutritional goals.
  • Low Sodium Content: With 400 mg of sodium per serving, this recipe can fit into a low-sodium diet when paired with low-sodium side dishes.
  • Supports Heart Health: This dish is approved for a Heart-Healthy diet, focusing on lean protein and low saturated fat.
  • Diabetic-Friendly: With only 6 grams of carbohydrates per serving, this recipe is a great choice for a blood-sugar-friendly meal.

FAQs About Panko-Crusted Tilapia

The key is a three-step process. First, make sure to pat the tilapia fillets completely dry with a paper towel to remove excess moisture. Second, use a binder like the lightly beaten egg in this recipe to help the crumbs adhere. Finally, gently press the panko mixture onto the surface of the fish to ensure it is fully coated before baking.

Yes, tilapia is a healthy choice. It is a lean source of protein and low in fat. Like many fish, it provides essential nutrients. It's a versatile fish that can be part of a balanced, heart-healthy diet.

Baking and air frying are two of the best methods for cooking tilapia, especially when you want a crispy crust without deep-frying. Both methods use dry heat that cooks the fish evenly and helps the coating become golden brown and crunchy.

More Heart-Healthy Seafood Recipes

Simple Baked & Air-Fried Fish

If you enjoyed this simple baked tilapia, you'll love exploring our other heart-healthy seafood recipes. These dishes feature lean proteins like fish and shrimp, all prepared with smart techniques to deliver incredible flavor without excess fat or sodium.

Healthy Sides for Tilapia

Vegetable & Grain Pairings

Find the perfect healthy side dish to complete your panko-crusted tilapia dinner and create a balanced meal. From vibrant roasted vegetables to wholesome grains, these easy-to-make recipes are packed with nutrients and designed to pair beautifully with fish.

Ingredients

Recipe yields 4 servings

Directions

  1. Step 1

    Preheat oven to 475°. Line a baking pan with foil.

  2. Step 2

    In a shallow bowl, slightly beat the egg. In another bowl, combine panko, parsley, basil, oregano, garlic powder, salt and black pepper.

  3. Step 3

    Dip the tilapia into the egg, shaking off excess, then into panko mixture, making sure to cover completely. Place breaded fish on prepared baking pan. Coat the fish lightly on both sides with nonstick cooking spray.

  4. Step 4

    Bake for 15 minutes, or until golden brown. Serve with lemon wedges. Serve immediately.

Nutrition Facts

Serving Size:
1/4 of the tilapia

181
Calories
3
g
Fat
117
mg
Cholesterol
400
mg
Sodium
6
g
Carbs
1
g
Sat. Fat
0
g
Fiber
30
g
Protein

Alternate Cooking Method: Air Fryer

For an even crispier crust, you can make this tilapia in an air fryer.

  • Preheat your air fryer to 400°F.
  • Prepare the fish exactly as directed in the recipe.
  • Lightly spray the air fryer basket with nonstick cooking spray and place the fillets in a single layer, ensuring they don't overlap.
  • Air fry for 10-12 minutes, flipping halfway through, until the fish is golden brown and cooked through.

Serving & Storage Tips

  • Serving: This tilapia pairs well with roasted vegetables like broccoli or asparagus, a simple side salad, or a serving of quinoa or brown rice.
  • Storage: Store leftover tilapia in an airtight container in the refrigerator for up to 3 days.
  • Reheating: For best results, reheat the tilapia in an oven or air fryer at 350°F for 5-7 minutes, or until warmed through. This will help the panko crust become crispy again. Avoid using a microwave, as it can make the coating soggy.

Ingredient Substitutions

If you need to avoid egg, you can use plain Greek yogurt or egg-free mayonnaise as a binder to help the panko crumbs stick to the fish.

Add 1-2 tablespoons of grated Parmesan cheese to the panko mixture for a savory, cheesy crust.

Substitute the panko bread crumbs with gluten-free panko or finely crushed rice-based cereal.

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