Heart Healthy Air Fryer Panko Crusted Tilapia

(5.0)
By Jessica Kielman
Published 8/20/2025
Dietitian Reviewed: Jane Schwartz, RDN, CLT
Approved for These Diets:
Heart Healthy | Diabetic
Heart Healthy Air Fryer Panko Crusted Tilapia
Photo Credit: Baldwin Publishing Staff Photographer

This Heart Healthy Air Fryer Panko Crusted Tilapia is a quick, crispy, and flavorful meal that's ready in under 30 minutes. Coated with fresh herbs and panko breadcrumbs, each fillet is air-fried to golden-brown perfection, creating a satisfyingly crunchy exterior while keeping the fish tender and flaky. It's a fantastic option for those looking for heart-healthy tilapia recipes and is also diabetic-friendly.

For more healthy meals, check out our full collection of heart-healthy air fryer recipes.

Don't have an air fryer? You can easily make Panko Crusted Tilapia in your oven!

Total Time
30 minutes
Servings
5
Calories
181

Can I make Panko-Crusted Tilapia in the oven?

Yes, you can bake this Panko-Crusted Tilapia in the oven for a similar crispy texture. Simply bake the tilapia in the oven for 15 minutes at 475°F on a lined baking sheet. You’ll know the fish is done when it reaches an internal temperature of 145°F and the outside is golden and crunchy. Here’s the full recipe for baking your Healthy Panko-Crusted Tilapia in the oven.

Key Health Highlights

  • Heart-healthy preparation with minimal added fat
  • High in lean protein (30 grams per serving)
  • Low in saturated fat and cholesterol-free
  • Approved to fit heart-healthy diet guidelines

FAQs About Air Fryer Panko Crusted Tilapia

Tilapia is ready when it flakes easily with a fork and reaches an internal temperature of 145°F.

Yes. Thaw it completely and pat dry before breading so the coating sticks.

Press the panko onto the fish gently, and don’t skip the light spray of oil before cooking. That helps the crust bind and brown.

More Healthy Fish Recipes

If you enjoyed this recipe, check out these other delicious and heart-healthy fish dishes:

Ingredients

Recipe yields 5 servings

How to Make Air Fryer Panko Crusted Tilapia

  1. Step 1

    Preheat air fryer to 400°F. Lightly grease the air fryer basket with nonstick cooking spray.

  2. Step 2

    In a shallow bowl, lightly beat the egg. In another bowl, combine panko, parsley, basil, oregano, garlic powder, salt and black pepper.

  3. Step 3

    Dip the tilapia into the egg, shaking off excess, then into panko mixture, making sure to cover completely. Place breaded fish in prepared air fryer basket. Coat the fish lightly on both sides with nonstick cooking spray.

  4. Step 4

    Air fry for 12 minutes, flipping halfway through, until golden brown and crispy. Garnish with sliced green onion and serve with lemon wedges. Serve immediately.

Nutrition Facts

Serving Size:
1/4 lb tilapia

181
Calories
3
g
Fat
0
mg
Cholesterol
400
mg
Sodium
6
g
Carbs
1
g
Sat. Fat
0
g
Fiber
30
g
Protein

Alternative Cooking Methods

Yes, you can bake this Panko-Crusted Tilapia in the oven for a similar crispy texture. Simply bake the tilapia in the oven for 15 minutes at 475°F on a lined baking sheet. You’ll know the fish is done when it reaches an internal temperature of 145°F and the outside is golden and crunchy. Here’s the full recipe for baking your Healthy Panko-Crusted Tilapia in the oven.

Serving & Storage Tips

  • Best served right after cooking for peak crunch
  • If storing, refrigerate in an airtight container up to 2 days
  • Reheat in the air fryer for 3–4 minutes to restore crispness
  • Serve with one of our heart healthy side dishes, a healthy salad, or whole grain rice for a balanced meal

Ingredient Substitutions

No fresh herbs? 

Use 1 teaspoon each of dried parsley, basil, and oregano.

 

Out of tilapia? 

Try cod, haddock, or catfish fillets instead.

 

Don’t have an air fryer? 

Bake at 475°F for 15 minutes on a lined sheet pan.

 

Prefer gluten-free? 

Use gluten-free panko breadcrumbs.

Try More Heart Healthy Air Fryer Recipes