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Heart Healthy Turkey Broccoli Casserole

(5.0)
By Adam Fisher
Published 9/15/2025
Dietitian Reviewed: Christina Wright, RD, LDN
Approved for These Diets:
Heart Healthy | Gluten Free | Diabetic
Heart Healthy Turkey Broccoli Casserole
Photo Credit: Baldwin Publishing Staff Photographer
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f you are looking for heart-healthy comfort food, try our delicious healthy Turkey Broccoli Casserole. It's a low sodium, gluten-free, and diabetic casserole recipe made with lean turkey breast, fiber-rich broccoli, and gluten-free penne in a creamy sauce. it’s perfect for a heart healthy diet. Enjoy this quick and comforting meal for weeknight dinners or any time you crave nutritious comfort food. Our simple homemade sauce keeps it rich and creamy without excess sodium or fat.

Check out more heart healthy casseroles.

Total Time
45 minutes
Servings
10
Calories
290

What Makes These Heart Healthy Turkey Broccoli Casserole Healthy

This casserole is designed for a heart-healthy lifestyle by prioritizing whole foods and smart cooking techniques. By using lean protein, packing in fiber-rich vegetables, and creating a flavorful sauce from scratch, we control the sodium and saturated fat content without sacrificing the comforting flavor you expect from a classic casserole.

Key Health Highlights

  • Lean Protein Source: Made with cooked turkey breast, which is lower in saturated fat compared to other meats.
  • Low in Sodium: This recipe uses unsalted chicken stock and minimal added salt, putting you in control of the sodium content.
  • Rich in Fiber: Broccoli provides essential dietary fiber, which supports heart health and digestion.
  • Heart-Healthy Fats: The sauce uses olive oil, a source of monounsaturated fats, instead of butter or heavy cream.
  • Gluten-Free & Diabetic-Friendly: Uses certified gluten-free pasta and almond flour to meet specific dietary needs without spiking blood sugar.

FAQs About Heart Healthy Turkey Broccoli Casserole

To make a healthy casserole, focus on a few key principles: use lean proteins like turkey or chicken, include plenty of vegetables for fiber and nutrients, make your own sauce to control sodium and fat, and choose whole-grain or gluten-free pasta.

You can boost flavor without adding excess salt by using a variety of herbs and spices. This recipe uses thyme, sage, paprika, and garlic. Other great options include onion powder, smoked paprika, or a pinch of red pepper flakes for gentle heat.

A great substitute is a homemade creamy sauce like the one in this recipe. By creating a roux with a healthy fat (olive oil) and a thickener (almond flour or cornstarch) and then whisking in milk and broth, you can achieve a rich, creamy texture with significantly less sodium and fewer processed ingredients.

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Ingredients

Recipe yields 10 servings

Casserole

Topping

Directions

Casserole

  1. Step 1

    Preheat oven to 350°F and lightly grease a 9 x 13 casserole dish with nonstick cooking spray.

  2. Step 2

    Cook the pasta in lightly salted water to al dente according to package directions. During the last 3 minutes of cooking the pasta, add the broccoli florets. Before draining the pasta and broccoli, reserve ½ cup of the pasta water. Drain and transfer the pasta and broccoli to the prepared casserole dish.

  3. Step 3

    In a medium saucepan, heat the oil over medium heat. Add the shallot and cook until it begins to brown and turns translucent. Add the garlic and flour; cook for 1 minute.

  4. Step 4

    Add the broth, reserved water and milk while whisking constantly until fully incorporated. Add the cornstarch and stir until completely dissolved. Bring the mixture to a simmer and cook until the sauce begins to thick, about 3 to 5 minutes.

  5. Step 5

    Remove from heat. Add the turkey, black pepper, thyme, sage, paprika and salt; stir until well combined. Pour turkey mixture over the pasta and gently stir to combine. Top with shredded cheddar cheese.

Topping

  1. Step 1

    In a small mixing bowl, combine the corn flakes and butter. Sprinkle evenly over the casserole.

  2. Step 2

    Bake uncovered for 15 to 20 minutes, until casserole is hot and bubbling in the center. Remove from oven and allow to rest for 5 minutes. Garnish with sliced green onion and enjoy immediately.

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Nutrition Facts

Serving Size:
1/2 cup

290
Calories
9
g
Fat
21
mg
Cholesterol
537
mg
Sodium
44
g
Carbs
2
g
Sat. Fat
4
g
Fiber
15
g
Protein
3
g
Sugars

Serving & Storage Tips

  • Serving: For a balanced meal, serve the casserole with a fresh green salad with a light vinaigrette.
  • Storage: Store any leftovers in an airtight container in the refrigerator for up to 3 days.
  • Reheating: Reheat individual portions in the microwave until hot and bubbling. You can also reheat the entire casserole in a 350°F oven for 15-20 minutes, or until heated through.

Ingredient Substitutions

  • For Ground Turkey: You can easily substitute 1 cup of cooked, shredded turkey with 1 cup of cooked, lean ground turkey. Brown the ground turkey with the shallots and garlic before making the sauce. 
  • Using Leftover Turkey: This recipe is perfect for using leftover holiday turkey. Simply shred or dice the cooked turkey and add it as directed.
  • To Add Rice: For a version with rice, you can substitute the pasta with 2 cups of cooked brown rice. Add the cooked rice to the casserole dish with the steamed broccoli and proceed with the recipe.

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