(5.0)
By Judy Capodanno
Published 9/15/2025
Dietitian Reviewed: Jane Schwartz, RDN, CLT
Approved for These Diets:
Heart Healthy | Diabetic | Vegetarian
Heart Healthy Vegetable Baked Ziti
Photo Credit: Baldwin Publishing Staff Photographer

Vegetable Baked Ziti brings homestyle Italian and heart-healthy ingredients together in one luscious casserole dish. The result is a Parmesan-topped masterpiece of cheesy noodles and tender veggies that you’re sure to love. This version keeps sodium low without sacrificing any of the classic, comforting flavor.

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Total Time
120 minutes
Servings
8
Calories
224

What Makes These Heart Healthy Vegetable Baked Ziti Healthy

  • It’s packed with a variety of roasted vegetables like bell peppers, zucchini, and squash, which provide essential fiber, vitamins, and antioxidants.
  • The recipe uses heart-healthy olive oil instead of butter, providing beneficial monounsaturated fats.
  • Flavor is built from herbs, garlic, and onions, allowing for a significantly lower sodium content (just 219mg per serving) compared to traditional recipes.

Key Health Highlights

  • Low in Sodium: Contains only 219mg of sodium per serving, making it an excellent choice for a low-sodium diet.
  • Low in Saturated Fat: With just 2g of saturated fat per serving, this dish supports cardiovascular health.
  • Diabetic-Friendly: This recipe is approved for a diabetic diet, with a balanced nutritional profile.
  • Vegetarian Main: A satisfying and complete vegetarian meal packed with plant-based nutrients and 10g of protein.
  • Good Source of Vitamin C: Bell peppers provide a significant amount of your daily Vitamin C, an important antioxidant.

FAQs About Heart Healthy Vegetable Baked Ziti

Yes, pasta can absolutely be part of a heart-healthy diet. The key is to choose whole-grain pasta for more fiber, load it up with vegetables, use a low-sodium tomato sauce, and be mindful of high-fat additions like excessive cheese or cream.

For a healthier baked ziti, opt for part-skim mozzarella and a modest amount of genuinely-grated Parmesan. Part-skim mozzarella is lower in saturated fat, and because Parmesan has such a strong flavor, you can use less of it to get that savory, cheesy taste.

The healthiness of ziti, like any pasta, depends on the type you choose and what you serve with it. Choosing a multigrain or whole-wheat ziti increases its fiber content. This recipe makes it a healthy choice by combining it with nutrient-dense vegetables and a low-sodium sauce.

This recipe is already low in fat, but to reduce it further, you could use slightly less olive oil and opt for fat-free mozzarella cheese. The majority of the fat in this dish comes from heart-healthy olive oil and a moderate amount of cheese.

Heart-Healthy Main Dishes

Healthy Cooking Guides & Sides

Ingredients

Recipe yields 8 servings

Directions

  1. Step 1

    Preheat oven to 450°.

  2. Step 2

    On a baking sheet, toss the bell pepper, zucchini, squash, and onion strips with 1 tsp of the olive oil, 1/8 teaspoon of the salt, black pepper to taste and the dried herbs. Roast until tender, about 15 minutes. Set aside. Reduce the oven temperature to 350°.

  3. Step 3

    Meanwhile, in a large saucepan of boiling water, cook pasta over medium-high heat until just tender. Drain in a colander and set aside.

  4. Step 4

    In a large skillet, heat remaining 2 teaspoons oil over medium-high heat until hot. Add chopped onion and garlic and sauté for 4 to 5 minutes, until onion is softened. Add tomatoes and bring to a boil. Reduce heat and simmer until sauce thickens, about 15 minutes, stirring occasionally. Add remaining 1/8 teaspoon salt, black pepper to taste and parsley and simmer another 5 minutes, stirring occasionally.

  5. Step 5

    In a large bowl, mix together cooked pasta, reserved vegetables, 1/2 cup of the mozzarella, 2 tablespoons of the Parmesan, and all but 1/4 cup of the tomato sauce. In a 13 x 9-inch baking dish, spread the remaining 1/4 cup tomato sauce. Pour in pasta mixture and top with remaining 1/2 cup mozzarella. Sprinkle with remaining 2 tablespoons Parmesan. Bake for 40 minutes, or until cheese is melted.

Nutrition Facts

Serving Size:
1/2 cup

224
Calories
6
g
Fat
10
mg
Cholesterol
219
mg
Sodium
33
g
Carbs
2
g
Sat. Fat
2
g
Fiber
10
g
Protein
4
g
Sugars

Alternative Cooking Methods

For a quicker version, you can boil the pasta and simmer the sauce on the stovetop while the vegetables roast. If you don't have an oven-safe baking dish, you can assemble and bake this in a large, oven-safe cast-iron skillet.

Serving & Storage Tips

  • Serving: Serve immediately from the oven for the best cheesy texture. A simple green salad makes a great pairing.
  • Storage: Store leftovers in an airtight container in the refrigerator for up to 4 days.
  • Freezing: This casserole freezes well. Assemble the ziti in a freezer-safe dish but do not bake. Cover tightly and freeze for up to 3 months. Thaw in the refrigerator overnight before baking as directed, adding 10-15 minutes to the baking time.
  • Reheating: Reheat individual portions in the microwave until hot. To reheat a larger portion, place in an oven-safe dish, cover with foil, and bake at 350°F (175°C) until warmed through.

Ingredient Substitutions

  • For the Pasta: Any short, tubular pasta works well. Try whole-wheat penne or rigatoni for extra fiber.

  • For the Cheese: To make this even lower in fat, you can use fat-free mozzarella. If you don't have Parmesan, Pecorino Romano is a good, salty substitute (use a little less).

  • For the Vegetables: Feel free to use other roasting vegetables you have on hand, such as mushrooms, eggplant, or broccoli florets.

  • To Add Protein: For a non-vegetarian version, you could add cooked, lean ground turkey to the sauce.

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