Mediterranean Breakfast Casserole

(5.0)
By Adam Fisher
Published 9/16/2025
Dietitian Reviewed: Erin McNamara, RDN, LDN, CLT
Approved for These Diets:
Heart Healthy | Low Sodium | High Protein | Gluten Free | Diabetic | Mediterranean | GLP-1 | Vegetarian
Mediterranean Breakfast Casserole
Photo Credit: Baldwin Publishing Staff Photographer
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This easy Mediterranean Breakfast Casserole recipe is baked to perfection with a vibrant blend of fresh vegetables and protein-packed eggs. Ready in under an hour, this Mediterranean diet recipe is ideal for quick and healthy breakfast meal prep or holiday brunches. You will love how it is loaded with superfoods, including antioxidant-rich spinach and fluffy quinoa, along with a tangy combination of low-fat feta and cottage cheese. And no need to add extra salt! Infused with a fragrant mixture of fresh basil, parsley and oregano, this low sodium breakfast casserole is naturally packed with flavor.

Eating healthy in the morning is easy when you try any of our delicious heart-healthy breakfast recipes. And if you are entertaining, check out more of our healthy casserole recipes where you’ll find a tasty variety of breakfast-friendly recipes. This casserole is also perfect for making the night before to save time on busy mornings.

Total Time
50 minutes
Servings
12
Calories
132

What Makes These Mediterranean Breakfast Casserole Healthy

This Mediterranean Breakfast Casserole is designed to be both delicious and nutritious, making it an ideal choice for a healthy start to your day. It prioritizes whole foods and lean protein over processed ingredients and excess salt, aligning perfectly with a heart-healthy eating pattern.

Key Health Highlights

  • Low in Sodium: With only 147 mg of sodium per serving, this dish gets its flavor from herbs and vegetables instead of salt, supporting blood pressure management.
  • High in Protein: Each serving provides 11 grams of protein from eggs and cottage cheese, helping to keep you full and satisfied throughout the morning.
  • Packed with Vegetables: Loaded with spinach, mushrooms, and bell peppers, this casserole is an excellent source of fiber, vitamins, and antioxidants.
  • Heart-Healthy Fats: The recipe uses olive oil, a cornerstone of the Mediterranean diet known for its monounsaturated fats.
  • Naturally Gluten-Free: By using quinoa as its base instead of bread, this casserole is a great option for those with gluten sensitivities.

FAQs About Mediterranean Breakfast Casserole

Yes, eggs are a great source of protein and are welcome in moderation on the Mediterranean diet. The diet emphasizes whole foods, and eggs fit well within that pattern, typically enjoyed a few times a week.

Absolutely. This recipe is perfect for making ahead. You can fully assemble the casserole in the baking dish, cover it tightly, and refrigerate it overnight. When you're ready, bake it straight from the fridge, adding about 5-10 minutes to the total baking time.

A watery casserole is usually caused by excess moisture from the vegetables. To prevent this, it's important to cook the vegetables thoroughly as directed in Step 3 to allow their water to evaporate before they are added to the casserole. Also, ensure any fresh spinach is just wilted, not overly cooked.

Typical breakfasts often include whole grains (like oats or quinoa), fresh fruit, nuts, seeds, yogurt, and healthy fats. This casserole aligns perfectly by combining protein-rich eggs with whole-grain quinoa and plenty of fresh vegetables.

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Ingredients

Recipe yields 12 servings

Directions

  1. Step 1

    Preheat oven to 350°F. Grease a 9x13-inch casserole dish with nonstick cooking spray; set aside.

  2. Step 2

    In a large mixing bowl, whisk together eggs, egg whites and milk; set aside.

  3. Step 3

    In a large skillet, heat the oil over medium heat until it begins to shimmer. Add onion, oregano, and black pepper. Cook, stirring occasionally, for 6 to 8 minutes, or until soft. Add garlic and cook until fragrant, about 30 seconds. Add the mushrooms, red bell pepper, green bell pepper, and zucchini, and cook, stirring occasionally, for 5 minutes. Add the spinach, basil, and parsley, tossing until spinach is just wilted, about 1 minute. Remove from heat.

  4. Step 4

    Spread 1 cup quinoa in an even layer in the prepared casserole dish. Spread half of the vegetable mixture on top of the quinoa, followed by half of the cottage cheese. Add a second layer of quinoa followed by the remaining vegetable mixture. Spoon the remaining cottage cheese on top in small dollops. Pour in the egg mixture and top with crumbled feta cheese.

  5. Step 5

    Bake for 40 to 45 minutes, or until eggs are set. Let stand 5 minutes before slicing and serving. Garnish with chopped basil and enjoy!

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Nutrition Facts

Serving Size:
1/2 cup

132
Calories
4
g
Fat
67
mg
Cholesterol
147
mg
Sodium
13
g
Carbs
1
g
Sat. Fat
2
g
Fiber
11
g
Protein
5
g
Sugars

For Individual Portions

For built-in portion control, you can bake this casserole in a standard 12-cup muffin tin. Grease the tin well with non-stick spray, divide the mixture evenly among the cups, and bake at 350°F for 20-25 minutes, or until the centers are set.

Serving & Storage Tips

  • Make-Ahead: Assemble the entire casserole in the baking dish (without baking), cover tightly with foil or plastic wrap, and refrigerate for up to 24 hours.
  • Storage: Store cooled leftovers in an airtight container in the refrigerator for up to 4 days.
  • Reheating: Reheat individual slices in the microwave for 60-90 seconds or in a toaster oven at 350°F for about 10 minutes, until warmed through.

Ingredient Substitutions

  • For a different flavor: Try adding 1 cup of cooked, crumbled low-sodium chicken or turkey sausage for an extra protein boost.
  • Low-Carb Version: You can omit the quinoa for a lower-carb option. The casserole will be less dense but still delicious and packed with flavor.
  • Other Vegetables: Feel free to swap in other hearty vegetables you have on hand, such as chopped asparagus, broccoli florets, or kale (sautéed until wilted).

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